Requirement for Interaction of PI3-Kinase p110α with RAS in Lung Tumor Maintenance
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چکیده
منابع مشابه
Requirement for Interaction of PI3-Kinase p110α with RAS in Lung Tumor Maintenance
RAS proteins directly activate PI3-kinases. Mice bearing a germline mutation in the RAS binding domain of the p110α subunit of PI3-kinse are resistant to the development of RAS-driven tumors. However, it is unknown whether interaction of RAS with PI3-kinase is required in established tumors. The need for RAS interaction with p110α in the maintenance of mutant Kras-driven lung tumors was explore...
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ژورنال
عنوان ژورنال: Cancer Cell
سال: 2013
ISSN: 1535-6108
DOI: 10.1016/j.ccr.2013.09.012